The Transcriptome of the Human Pathogen Trypanosoma brucei at Single-Nucleotide Resolution

Abstract excerpt

The genome of Trypanosoma brucei, the causative agent of African trypanosomiasis, was published five years ago, yet identification of all genes and their transcripts remains to be accomplished. Annotation is challenged by the organization of genes transcribed by RNA polymerase II (Pol II) into long unidirectional gene clusters with no knowledge of how transcription is initiated. Here we report a single-nucleotide...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biochemical and Molecular Research
• Share to CRISPR and Genetic Engineering
• Share to Trypanosoma species research and implications