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Article

Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes.

PLoS genetics - 1 Feb 2020

Kieft Rudo, Zhang Yang, Marand Alexandre P, Moran Jose Dagoberto, Bridger Robert, Wells Lance, Schmitz Robert J, Sabatini Robert

Abstract excerpt

Base J, β-D-glucosyl-hydroxymethyluracil, is a modification of thymine DNA base involved in RNA Polymerase (Pol) II transcription termination in kinetoplastid protozoa. Little is understood regarding how specific thymine residues are targeted for J-modification or the mechanism of J regulated transcription termination. To identify proteins involved in J-synthesis, we expressed a tagged version of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32084124
DOI: 10.1371/journal.pgen.1008390
PMCID: PMC7055916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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