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Mono-allelic epigenetic regulation of bi-directional silencing of RNA Polymerase II polycistronic transcription initiation in <i>Trypanosoma brucei</i>

2024-06-22

Abstract excerpt

<h4>ABSTRACT</h4> Unique for a eukaryote, protein-coding genes in trypanosomes are arranged in polycistronic units (PTUs). This genome arrangement has led to a model where Pol II transcription of PTUs is unregulated and that changes in gene expression are entirely post-transcriptional. Trypanosoma brucei brucei is unable to infect humans because of its susceptibility to an innate immune complex, trypanosome lytic...

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Literature Corpus work
0b5c1e85-4b45-5de1-9a0b-8a257e213a44
DOI
10.1101/2024.06.21.600114
Open publication

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Mono-allelic epigenetic regulation of bi-directional silencing of RNA Polymerase II polycistronic transcription initiation in <i>Trypanosoma brucei</i>DOI 10.1101/2024.06.21.600114
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