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Genome-wide overexpression screen reveals a novel transcription termination factor in <i>Trypanosoma brucei</i>

2025-09-05

Abstract excerpt

<h4>ABSTRACT</h4> Trypanosoma brucei is a protozoan parasite that causes African trypanosomiasis. We performed an overexpression library screen to gain insights into essential cellular processes in T. brucei and identified genes whose overexpression impaired parasite growth. One of the three top-ranking candidates we validated exhibited a notable phenotype. Tb FOP, an uncharacterized protein, has an N-terminal...

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Literature Corpus work
9c7adc97-4ad4-50e7-99ea-e78d250e06f1
DOI
10.1101/2025.09.02.673782
Open publication

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Genome-wide overexpression screen reveals a novel transcription termination factor in <i>Trypanosoma brucei</i>DOI 10.1101/2025.09.02.673782
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