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The clinical applicability of polygenic risk scores for LDL-cholesterol: considerations, current evidence and future perspectives

4 Feb 2021

Abstract excerpt

PURPOSE OF REVIEW: The current review describes the development, clinical relevance and potential caveats of polygenic risk scores (PRS) for LDL cholesterol (LDL-C). RECENT FINDINGS: In recent years, a large number of common variants have been shown to have a small effect on LDL-C levels. The aggregate effect of all of these variants on LDL-C levels can be captured in a PRS and an elevated number of LDL-C...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33560669
DOI: 10.1097/mol.0000000000000741

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