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Article

Polygenic risk score predicts prevalence of cardiovascular disease in patients with familial hypercholesterolemia.

Journal of clinical lipidology - 1 Jan 2000

Paquette Martine, Chong Michael, Thériault Sébastien, Dufour Robert, Paré Guillaume, Baass Alexis

Abstract excerpt

BACKGROUND: Although familial hypercholesterolemia (FH) is a severe monogenic disease, it has been shown that clinical risk factors and common genetic variants can modify cardiovascular disease (CVD) risk. OBJECTIVE: The aim of the study was to evaluate the polygenic contribution to lipid traits and CVD in FH using genetic risk scores (GRSs). METHODS: Among the 20,434 subjects attending the lipid clinic, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28456682
DOI: 10.1016/j.jacl.2017.03.019

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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