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Article

Polygenic risk scores for low-density lipoprotein cholesterol and familial hypercholesterolemia.

Journal of human genetics - 1 Nov 2021

Nomura Akihiro, Sato Takehiro, Tada Hayato, Kannon Takayuki, Hosomichi Kazuyoshi, Tsujiguchi Hiromasa, Nakamura Hiroyuki, Takamura Masayuki, Tajima Atsushi, Kawashiri Masa-Aki

Abstract excerpt

Familial hypercholesterolemia (FH) is an autosomal dominant monogenic disorder characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased risk of premature coronary artery disease (CAD). Recently, it has been shown that a high polygenic risk score (PRS) could be an independent risk factor for CAD in FH patients of European ancestry. However, it is uncertain whether PRS is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33967275
DOI: 10.1038/s10038-021-00929-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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