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Article

Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2016

Wang Jian, Dron Jacqueline S, Ban Matthew R, Robinson John F, McIntyre Adam D, Alazzam Maher, Zhao Pei Jun, Dilliott Allison A, Cao Henian, Huff Murray W, Rhainds David, Low-Kam Cécile, Dubé Marie-Pierre, Lettre Guillaume, Tardif Jean-Claude, Hegele Robert A

Abstract excerpt

OBJECTIVE: Next-generation sequencing technology is transforming our understanding of heterozygous familial hypercholesterolemia, including revision of prevalence estimates and attribution of polygenic effects. Here, we examined the contributions of monogenic and polygenic factors in patients with severe hypercholesterolemia referred to a specialty clinic. APPROACH AND RESULTS: We applied targeted next-generation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27765764
DOI: 10.1161/ATVBAHA.116.308027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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