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Article

The Association of Serum Uric Acid Level, Gout, and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Ou Ya-Nan, Zhao Bing, Fu Yan, Sheng Ze-Hu, Gao Pei-Yang, Tan Lan, Yu Jin-Tai

Abstract excerpt

BACKGROUND: The relationship between serum uric acid (UA) and Alzheimer's disease (AD) risk still remained ambiguous despite extensive attempts. OBJECTIVE: Via the two-sample Mendelian randomization (MR) design, we aimed to examine the bidirectional causal relationships of serum UA, gout, and the risk of AD. METHODS: Genetic variants of UA, gout, and AD were extracted from published genome-wide association...

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PMID: 35964198
DOI: 10.3233/JAD-220649

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