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Article

[Plasma metabolites mediates the causal effect of inflammatory proteins on Alzheimer's disease: a Mendelian randomization study].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 20 Feb 2026

Chen Meimei, Huang Ruina, Yang Zhaoyang

Abstract excerpt

OBJECTIVES: To investigate the causal relationship between inflammatory proteins and Alzheimer's disease (AD) and the mediating role of plasma metabolites therein. METHODS: Using Mendelian mandomization (MR) methods and publicly available genome-wide association study (GWAS) data, we selected 91 single nucleotide polymorphisms (SNPs) that were strongly linked to inflammatory proteins without reverse causality...

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Identifiers

PMID: 41633684
DOI: 10.12122/j.issn.1673-4254.2026.02.05
PMCID: PMC12867631

Genes

CXCL11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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