Progressive autoimmune beta cell insufficiency: occurrence in the absence of high-risk HLA alleles DR3, DR4.

doi:10.2337/diacare.8.5.477

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Article

Progressive autoimmune beta cell insufficiency: occurrence in the absence of high-risk HLA alleles DR3, DR4.

Diabetes care - 1 Jan 2000

Eisenbarth G S, Srikanta S, Fleischnick E, Ganda O P, Jackson R A, Brink S J, Soeldner J S, Yunis E J, Alper C

Abstract excerpt

In a prospective screening program for type I diabetes mellitus, we identified a unique family in which several members (mother and three siblings) expressed an unusual set of HLA-DR alleles (DR2+, DR3/4-) and were in different phases of immunologically mediated islet beta cell dysfunction. Immunologic and/or clinical manifestations of type I diabetes were absent in all siblings not sharing both HLA haplotypes in...

Topics

Adolescent
Adult
Alleles
Autoimmune Diseases
Child
Diabetes Mellitus, Type 1
Female
HLA-DR Antigens
HLA-DR2 Antigen
HLA-DR3 Antigen
HLA-DR4 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocompatibility Antigens Class II

Humans

Male

Middle Aged

Pedigree

Prediabetic State

Risk

Source

Open in PubMed

Identifiers

PMID: 3876922
DOI: 10.2337/diacare.8.5.477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3876922-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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