Article
Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease.
Molecular medicine (Cambridge, Mass.) - 1 Jul 1995
Honeyman M C, Harrison L C, Drummond B, Colman P G, Tait B D
Abstract excerpt
BACKGROUND: Individuals at risk for insulin-dependent diabetes mellitus (IDDM), with an affected first-degree relative, can be identified by the presence of islet cell antibodies (ICA). ICA-positive relatives progress at variable rates to IDDM and identification of those at highest risk is a prer...
Topics
- Adult
- Age Factors
- Alleles
- Child
- Diabetes Mellitus, Type 1
- Disease Progression
- Female
- Genes, MHC Class I
- Genes, MHC Class II
- HLA Antigens
- Histocompatibility Testing
- Humans
- Islets of Langerhans
- Male
- Phenotype
- Risk Factors