Article
Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes.
Clinical and experimental immunology - 1 Aug 2007
Truyen I, De Grijse J, Weets I, Kaufman L, Pipeleers L, Nanos N, Decochez K, Hilbrands R, Kaufman J-M, Keymeulen B, Mathieu C, Van Gaal L, Pipeleers D G, Gorus F K
Abstract excerpt
Prevention trials of type I diabetes are limited by recruitment of individuals at high risk of the disease. We investigated whether demographic and biological characteristics can identify rapid progressors among first-degree relatives of known patients at intermediate (< 10%) 5-year risk. Diabetes-associated antibodies, random proinsulin : C-peptide (PI/C) ratio and HLA DQ genotype were determined (repeatedly) in...
Topics
- Adolescent
- Adult
- Age Factors
- Autoantibodies
- Biomarkers
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Disease Progression
- Epidemiologic Methods
- Female
- Genetic Predisposition to Disease
- HLA-DQ Antigens