Article
Association of HLA-DQ genotype in autoantibody-negative and rapid-onset type 1 diabetes.
Diabetes care - 1 Dec 2002
Tanaka Shoichiro, Kobayashi Tetsuro, Nakanishi Koji, Koyama Rikako, Okubo Minoru, Murase Toshio, Odawara Masato, Inoko Hidetoshi
Abstract excerpt
OBJECTIVE: Some type 1 diabetic patients have a distinct phenotype characterized by the absence of pancreatic autoantibodies and fulminant clinical symptoms at onset, including marked hyperglycemia, severe diabetic ketoacidosis, and normal to near-normal HbA(1c) levels with complete destruction of beta-cells. However, little is known about genetic factors of this distinct subtype of diabetes (fulminant...
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