Article
[The role of genetic and immunological factors in the etiology of insulin-dependent diabetes].
Schweizerische medizinische Wochenschrift - 20 Jan 1990
Deschamps I, Hors J, Robert J J
Abstract excerpt
The mechanism of pancreatic B-cell destruction in type I (insulin-dependent) diabetes (IDDM) involves autoimmune phenomena based on genetic predisposition. The mechanism of action of the susceptibility genes is probably related to the function of the HLA molecules in the immune response. The genetic susceptibility is distinguished by increased frequency of the HLA antigens DR3 and DR4 and particularly their...
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