Article
Excess of maternal HLA-DR3 antigens in HLA DR3,4 positive type 1 (insulin-dependent) diabetic patients.
Diabetologia - 1 Jul 1990
Deschamps I, Hors J, Clerget-Darpoux F, Gardais E, Robert J J, Marcelli-Berge A, Lestradet H, Dausset J
Abstract excerpt
The susceptibility determinants of Type 1 (insulin-dependent) diabetes mellitus are known to be associated with both HLA-DR3 and DR4. In our study we wished to determine if the parental origin of these antigens could influence susceptibility to the disease. We analysed the inheritance of DR3 and DR4 haplotypes from the father or mother (DR3p, DR4p, DR3m and DR4m, respectively), in the index cases and in the...
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