Article
HLA class II alleles specify phenotypes of ketosis-prone diabetes.
Diabetes care - 1 Jun 2008
Nalini Ramaswami, Gaur Lakshmi K, Maldonado Mario, Hampe Christiane S, Rodriguez Lucille, Garza Gilberto, Lernmark Ake, Balasubramanyam Ashok
Abstract excerpt
OBJECTIVE: Ketosis-prone diabetes (KPD) comprises four subgroups based on the presence or absence of beta-cell autoantibodies (A+ or A-) and beta-cell functional reserve (beta+ or beta-). Genetic factors could contribute to their distinctive phenotypes. Our aim was to specify the role of HLA class II alleles associated with susceptibility or resistance to autoimmune type 1 diabetes in determining KPD phenotypes....
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