Article
Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes.
The Journal of clinical investigation - 1 Jun 1994
Pugliese A, Bugawan T, Moromisato R, Awdeh Z L, Alper C A, Jackson R A, Erlich H A, Eisenbarth G S
Abstract excerpt
Levels of insulin autoantibodies (IAA) vary among different first degree relatives of insulin-dependent diabetes mellitus patients, suggesting genetic regulation. We previously reported elevated IAA among DR4-positive at risk relatives. In this study, 72/82 at risk relatives were IAA positive, of whom 75% (54/72) carried DR4 versus 20% (2/10) of IAA-negative relatives (P = 0.0004). However, 69% (18/26) of...
Topics
- Alleles
- Amino Acid Sequence
- Autoantibodies
- Diabetes Mellitus, Type 1
- Female
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- Humans