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Article

Inhibition of mRNA nuclear export promotes SARS-CoV-2 pathogenesis

20 May 2024

Abstract excerpt

The nonstructural protein 1 (Nsp1) of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) is a virulence factor that targets multiple cellular pathways to inhibit host gene expression and antiviral response. However, the underlying mechanisms of the various Nsp1-mediated functions and their contributions to SARS-CoV-2 virulence remain unclear. Among the targets of Nsp1 is the mRNA (messenger ribonucleic...

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PMID: 38768348
DOI: 10.1073/pnas.2314166121

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