Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression.

Cell reports - 19 Oct 2021

Mendez Aaron S, Ly Michael, González-Sánchez Angélica M, Hartenian Ella, Ingolia Nicholas T, Cate Jamie H, Glaunsinger Britt A

Abstract excerpt

Nonstructural protein 1 (nsp1) is a coronavirus (CoV) virulence factor that restricts cellular gene expression by inhibiting translation through blocking the mRNA entry channel of the 40S ribosomal subunit and by promoting mRNA degradation. We perform a detailed structure-guided mutational analysis of severe acute respiratory syndrome (SARS)-CoV-2 nsp1, revealing insights into how it coordinates these activities...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anisotropy
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Protein Domains

Share to Ribosomes

Share to RNA Stability

Share to SARS-CoV-2

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34624207
DOI: 10.1016/j.celrep.2021.109841
PMCID: PMC8481097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression.PMID 34624207Read ↗

The N-Terminal and Central Domains of CoV-2 nsp1 Play Key Functional Roles in Suppression of Cellular Gene Expression and Preservation of Viral Gene ExpressionSemantic proximity Read ↗

Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiationSemantic proximity Read ↗

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2Semantic proximity Read ↗

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.Semantic proximity Read ↗

An evolutionarily conserved strategy for ribosome binding and inhibition by β-coronavirus non-structural protein 1Semantic proximity Read ↗

Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNASemantic proximity Read ↗

I(nsp1)ecting SARS-CoV-2–ribosome interactionsSemantic proximity Read ↗

SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translationSemantic proximity Read ↗

The impact of Coronavirus Nsp1 on host mRNA degradation is independent of its role in translation inhibitionSemantic proximity Read ↗

Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasionSemantic proximity Read ↗

The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translationSemantic proximity Read ↗

Targeting Stem-loop 1 of the SARS-CoV-2 5’UTR to suppress viral translation and Nsp1 evasionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.