Article

An evolutionarily conserved strategy for ribosome binding and inhibition by β-coronavirus non-structural protein 1

2023-06-08

Abstract excerpt

An important pathogenicity factor of SARS-CoV-2 and related coronaviruses is Nsp1, which suppresses host gene expression and stunts antiviral signaling. SARS-CoV-2 Nsp1 binds the ribosome to inhibit translation through mRNA displacement and induces degradation of host mRNAs through an unknown mechanism. Here we show that Nsp1-dependent host shutoff is conserved in diverse coronaviruses, but only Nsp1 from β-CoV in...

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Literature Corpus work: 51a0df4e-cd14-5a33-b544-66cd1e9723f2
DOI: 10.1101/2023.06.07.544141

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