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Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

5 Feb 2021

Abstract excerpt

The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host interactions involved in mechanisms of virulence. Here, we show that the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host messenger RNA (mRNA) export receptor heterodimer NXF1-NXT1, which is responsible for nuclear export of cellular...

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PMID: 33547084
DOI: 10.1126/sciadv.abe7386

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