Article

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

2020-05-18

Abstract excerpt

SARS-CoV-2 is the causative agent of the current COVID-19 pandemic. A major virulence factor of SARS-CoVs is the nonstructural protein 1 (Nsp1) which suppresses host gene expression by ribosome association via an unknown mechanism. Here, we show that Nsp1 from SARS-CoV-2 binds to 40S and 80S ribosomes, resulting in shutdown of capped mRNA translation both in vitro and in cells. Structural analysis by cryo-electro...

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Literature Corpus work: 94d3cde4-d017-584b-9b83-3122fa0071a5
DOI: 10.1101/2020.05.18.102467

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