Article
Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.
PloS one - 1 Jan 2013
Jauregui Andrew R, Savalia Dhruti, Lowry Virginia K, Farrell Cara M, Wathelet Marc G
Abstract excerpt
An epidemic of Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.