Article
Genotype-guided tacrolimus dosing in African-American kidney transplant recipients.
The pharmacogenomics journal - 1 Jan 2017
Sanghavi K, Brundage R C, Miller M B, Schladt D P, Israni A K, Guan W, Oetting W S, Mannon R B, Remmel R P, Matas A J, Jacobson P A
Abstract excerpt
Tacrolimus is dependent on CYP3A5 enzyme for metabolism. Expression of the CYP3A5 enzyme is controlled by several alleles including CYP3A5*1, CYP3A5*3, CYP3A5*6 and CYP3A5*7. African Americans (AAs) have on average higher tacrolimus dose requirements than Caucasians; however, some have requirements similar to Caucasians. Studies in AAs have primarily evaluated the CYP3A5*3 variant; however, there are other common...
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