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Article

Cost-effectiveness analysis of CYP3A5 genotype-guided tacrolimus dosing in solid organ transplantation using real-world data.

The pharmacogenomics journal - 15 May 2024

Deininger Kimberly M, Anderson Heather D, Patrinos George P, Mitropoulou Christina, Aquilante Christina L

Abstract excerpt

The objective of this study was to estimate the cost-effectiveness of CYP3A5 genotype-guided tacrolimus dosing in kidney, liver, heart, and lung transplant recipients relative to standard of care (SOC) tacrolimus dosing, from a US healthcare payer perspective. We developed decision-tree models to compare economic and clinical outcomes between CYP3A5 genotype-guided and SOC tacrolimus therapy in the first six...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 38750044
DOI: 10.1038/s41397-024-00334-1

Genes

CYP3A5
TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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