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Genotype-guided tacrolimus dosing: The role of CYP3A5 polymorphisms in optimising kidney transplant immunosuppression in Bhutan

2026-06-17

Abstract excerpt

<title>Abstract</title> <p> Tacrolimus is a critical component of immunosuppressive therapy in kidney transplantation, characterized by a narrow therapeutic index and significant interindividual variability, largely influenced by <italic>CYP3A5</italic> polymorphisms that affect tacrolimus trough concentrations. This study aimed to investigate the impact of higher tacrolimus doses and the required dose to achi...

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Literature Corpus work
11f2bb91-2d62-5d8d-af44-c257064a23dd
DOI
10.21203/rs.3.rs-9061942/v1
Open publication

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