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Article

A novel rat model harboring two BDNF gene mutations exhibiting autism-like behaviors and cognitive impairments.

Neuropharmacology - 15 Jun 2026

Xue Zeping, Lan Junying, Zhao Yueyang, Yu Peng, Liu Lei, Lu Bai, Yang Feng

Abstract excerpt

Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that occurs most frequently in early childhood, affecting approximately 1% of the global population. Currently, the elusive nature of the pathological mechanisms underlying ASD precludes the existence of a definitive, effective treatment approach. In this study, we have successfully generated a novel ASD rat model utilizing CRISPR/Cas9...

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Source

Identifiers

PMID: 41794282
DOI: 10.1016/j.neuropharm.2026.110911

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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