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A deconvolution method and its application in analyzing the cellular fractions in acute myeloid leukemia samples

23 Sept 2020

Abstract excerpt

BACKGROUND: The identification of cell type-specific genes (markers) is an essential step for the deconvolution of the cellular fractions, primarily, from the gene expression data of a bulk sample. However, the genes with significant changes identified by pair-wise comparisons cannot indeed represent the specificity of gene expression across multiple conditions. In addition, the knowledge about the identification...

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PMID: 32967610
DOI: 10.1186/s12864-020-06888-1

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