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Article

Longitudinal single-cell analysis reveals treatment-resistant stem and mast cells with potential treatments for pediatric AML.

Leukemia - 1 Nov 2025

Ohlstrom Denis, Bakhtiari Mojtaba, Mumme Hope, Michaud Marina, De Janon Gutierrez Alejandro, DeRyckere Deborah, Ferguson Katherine E, Chien Frank, Pilcher William, Satpathy Sarthak, Jordan Sean, Graham Douglas, Bhasin Swati, Bhasin Manoj

Abstract excerpt

Pediatric acute myeloid leukemia (pAML) is a heterogeneous malignancy driven by diverse cytogenetic mutations. While identification of cytogenetic lesions improved risk stratification, prognostication remains inadequate with 30% of standard-risk patients experiencing relapse within 5 years. To deeply characterize pAML heterogeneity and identify poor outcome-associated blast cell profiles, we performed an analysis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40931047
DOI: 10.1038/s41375-025-02748-7

Genes

RUNX1
FLT3
RUNX1T1
CBFB
MYH11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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