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Article

Genetic basis of early onset and progression of type 2 diabetes in South Asians.

Nature medicine - 1 Jan 2025

Hodgson Sam, Williamson Alice, Bigossi Margherita, Stow Daniel, Jacobs Benjamin M, Samuel Miriam, Gafton Joseph, Zöllner Julia, Spreckley Marie, Langenberg Claudia, van Heel David A, Mathur Rohini, Siddiqui Moneeza K, Finer Sarah

Abstract excerpt

South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass index (BMI). However, reasons for this are poorly understood because genetic research is largely focused on European ancestry groups. We used recently derived multi-ancestry partitioned polygenic scores (pPSs) to elucidate underlying etiological pathways British Pakistani and British Bangladeshi individuals with T2D...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39592779
DOI: 10.1038/s41591-024-03317-8
PMCID: PMC11750703

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