Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.

doi:10.1155/2023/8883199

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Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.

Pediatric diabetes - 1 Jan 2023

Srinivasan Shylaja, Chen Ling, Udler Miriam, Todd Jennifer, Kelsey Megan M, Haymond Morey W, Arslanian Silva, Zeitler Philip, Gubitosi-Klug Rose, Nadeau Kristen J, Kutney Katherine, White Neil H, Li Josephine H, Perry James A, Kaur Varinderpal, Brenner Laura, Mercader Josep M, Dawed Adem, Pearson Ewan R, Yee Sook-Wah, Giacomini Kathleen M, Pollin Toni, Florez Jose C

Abstract excerpt

Metformin is the first-line treatment for type 2 diabetes (T2D) in youth but with limited sustained glycemic response. To identify common variants associated with metformin response, we used a genome-wide approach in 506 youth from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study and examined the relationship between T2D partitioned polygenic scores (pPS), glycemic traits, and...

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Identifiers

PMID: 38590442
DOI: 10.1155/2023/8883199
PMCID: PMC11000826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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