Interaction between fatty pancreas disease and genetically predicted glucose-dependent insulinotropic polypeptide on incident type 2 diabetes: evidence from the UK Biobank.

Abstract excerpt

Purpose: Glucose-dependent insulinotropic polypeptide (GIP) plays a crucial role in lipid metabolism. The effect of GIP on pancreatic lipid and whether it modulates risk of type 2 diabetes (T2D) associated with fatty pancreas remain unknown. The aim of this study was to investigate the interaction between genetically predicted GIP levels and fatty pancreas in the development of T2D. Methods: This is a large-scale...

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