Article

A dish-to-biobank framework links β-cell nutrient-stress programs to genetic and dietary risk for Type 2 Diabetes

2026-06-16

Abstract excerpt

Type 2 diabetes (T2D) arises from genetic susceptibility and chronic metabolic stress, but whether these converge on shared molecular programs in human populations remains unclear. Here, we develop a dish-to-biobank framework linking controlled β-cell perturbation to population-scale disease genetics through the circulating plasma proteome, and apply it to T2D. scRNA-seq of human stem cell–derived islets under fac...

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Literature Corpus work: a733ae98-3471-53c2-888a-199d730b8f9d
DOI: 10.64898/2026.06.12.731989

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