Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-genome analysis of a daptomycin-susceptible enterococcus faecium strain and its daptomycin-resistant variant arising during therapy.

Antimicrobial agents and chemotherapy - 1 Jan 2013

Tran Truc T, Panesso Diana, Gao Hongyu, Roh Jung H, Munita Jose M, Reyes Jinnethe, Diaz Lorena, Lobos Elizabeth A, Shamoo Yousif, Mishra Nagendra N, Bayer Arnold S, Murray Barbara E, Weinstock George M, Arias Cesar A

Abstract excerpt

Development of daptomycin (DAP) resistance in Enterococcus faecalis has recently been associated with mutations in genes encoding proteins with two main functions: (i) control of the cell envelope stress response to antibiotics and antimicrobial peptides (LiaFSR system) and (ii) cell membrane phospholipid metabolism (glycerophosphoryl diester phosphodiesterase and cardiolipin synthase [cls]). However, the genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Cell Wall

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Daptomycin

Share to Enterococcus faecium

Share to Genome, Bacterial

Share to Gram-Positive Bacterial Infections

Share to Lipid Metabolism

Share to Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23114757
DOI: 10.1128/AAC.01454-12
PMCID: PMC3535923

Genes

DAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-genome analysis of a daptomycin-susceptible enterococcus faecium strain and its daptomycin-resistant variant arising during therapy.PMID 23114757Read ↗

Genetic Basis for Daptomycin Resistance in EnterococciSemantic proximity Read ↗

Genetic basis for in vivo daptomycin resistance in enterococci.Semantic proximity Read ↗

Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureusSemantic proximity Read ↗

LiaR‐independent pathways to daptomycin resistance in Enterococcus faecalis reveal a multilayer defense against cell envelope antibioticsSemantic proximity Read ↗

Rising daptomycin resistance in <i>Enterococcus faecium</i> across a hospital system occurred via rampant recurrent evolution and occasional transmission between patientsSemantic proximity Read ↗

New Mutations in cls Lead to Daptomycin Resistance in a Clinical Vancomycin- and Daptomycin-Resistant Enterococcus faecium StrainSemantic proximity Read ↗

Genotypic and phenotypic evaluation of the evolution of high-level daptomycin nonsusceptibility in vancomycin-resistant Enterococcus faecium.Semantic proximity Read ↗

Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci.Semantic proximity Read ↗

Evolution of high-level daptomycin resistance in Enterococcus faecium during daptomycin therapy is associated with limited mutations in the bacterial genome.Semantic proximity Read ↗

A Daptomycin Resistance-Conferring cls1 I269T Mutation in Enterococcus faecium and its Global Prevalence.Semantic proximity Read ↗

Environment Shapes the Accessible Daptomycin Resistance Mechanisms in <i>Enterococcus faecium</i>Semantic proximity Read ↗

Whole-genome sequencing based characterization of antimicrobial resistance in Enterococcus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.