Article
LC-MS/MS characterization of phospholipid content in daptomycin-susceptible and -resistant isolates of Staphylococcus aureus with mutations in mprF.
Molecular membrane biology - 1 Feb 2012
Rubio Aileen, Moore Jeff, Varoglu Mustafa, Conrad Mary, Chu Min, Shaw Walter, Silverman Jared A
Abstract excerpt
Daptomycin (DAP) is a cyclic lipopeptide antibiotic used for the treatment of certain Staphylococcus aureus infections. Although rare, strains have been isolated that are DAP resistant. These strains usually have mutations in mprF, a gene encoding a membrane protein with both lysylphosphatidylglycerol (LPG) synthase and flippase activities. Because ΔmprF strains have increased DAP susceptibility, the mechanism of...
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