Article
Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein.
Nature communications - 13 May 2021
Wang Pui, Lau Siu-Ying, Deng Shaofeng, Chen Pin, Mok Bobo Wing-Yee, Zhang Anna Jinxia, Lee Andrew Chak-Yiu, Chan Kwok-Hung, Tam Rachel Chun-Yee, Xu Haoran, Zhou Runhong, Song Wenjun, Liu Li, To Kelvin Kai-Wang, Chan Jasper Fuk-Woo, Chen Zhiwei, Yuen Kwok-Yung, Chen Honglin
Abstract excerpt
SARS-CoV-2 is of zoonotic origin and contains a PRRA polybasic cleavage motif which is considered critical for efficient infection and transmission in humans. We previously reported on a panel of attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction of the spike protein. Here, we characterize pathogenicity, immunogenicity, and protective ability of a further cell-adapted SARS-CoV-2 variant,...
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