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Article

Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis.

Cancer discovery - 4 Sept 2024

Demajo Santiago, Ramis-Zaldivar Joan E, Muiños Ferran, Grau Miguel L, Andrianova Maria, López-Bigas Núria, González-Pérez Abel

Abstract excerpt

Clonal hematopoiesis (CH) is a phenomenon of clonal expansion of hematopoietic stem cells driven by somatic mutations affecting certain genes. Recently, CH has been linked to the development of hematologic malignancies, cardiovascular diseases, and other conditions. Although the most frequently mutated CH driver genes have been identified, a systematic landscape of the mutations capable of initiating this...

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Source

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Identifiers

PMID: 38722595
DOI: 10.1158/2159-8290.CD-23-1416
PMCID: PMC11372364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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