Article

Unified somatic calling and machine learning-based classification enhance the discovery of clonal hematopoiesis of indeterminate potential

2024-04-27

Abstract excerpt

<h4>ABSTRACT</h4> Clonal hematopoiesis (CH) of indeterminate potential (CHIP), driven by somatic mutations in leukemia-associated genes, confers increased risk of hematologic malignancies, cardiovascular disease and all-cause mortality. In blood of healthy individuals, small CH clones can expand over time to reach 2% variant allele frequency (VAF), the current threshold for CHIP. Nevertheless, reliable detection...

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Literature Corpus work: cb8e1bb3-555c-579d-b03f-b1fbf8b98773
DOI: 10.1101/2024.04.22.590586

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