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Complete biosynthesis of QS-21 in engineered yeast

8 May 2024

Abstract excerpt

Abstract QS-21 is a potent vaccine adjuvant and remains the only saponin-based adjuvant that has been clinically approved for use in humans 1,2 . However, owing to the complex structure of QS-21, its availability is limited. Today, the supply depends on laborious extraction from the Chilean soapbark tree or on low-yielding total chemical synthesis 3,4 . Here we demonstrate the complete biosynthesis of QS-21 and...

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PMID: 38720067
DOI: 10.1038/s41586-024-07345-9

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