Article

A truncation library for the soluble production of squalene synthase from <i>Candida albicans</i> in <i>Escherichia coli</i>

2025-02-06

Abstract excerpt

The rising global burden of infectious fungal disease and the steady increase of resistance by fungal pathogens to available treatments necessitate a concerted effort to develop new antifungal medicines. Squalene synthase is a critical enzyme in the synthesis of ergosterol, a fungal-specific sterol, and has not yet been exploited as an antifungal drug target for pathogenic yeast. In this study, we heterologously p...

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Literature Corpus work: b780942a-c65e-5ab1-8270-51c212f1cb6c
DOI: 10.1101/2025.02.06.636915

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