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High-Titer Production of the Fungal Anhydrotetracycline, TAN-1612, in Engineered Yeasts

14 Jun 2022

Abstract excerpt

Antibiotic resistance is a growing global health threat, demanding urgent responses. Tetracyclines, a widely used antibiotic class, are increasingly succumbing to antibiotic resistance; generating novel analogues is therefore a top priority for public health. Fungal tetracyclines provide structural and enzymatic diversity for novel tetracycline analogue production in tractable heterologous hosts, like yeasts, to...

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PMID: 35699947
DOI: 10.1021/acssynbio.2c00116

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