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Article

De Novo Biosynthesis of Vindoline and Catharanthine in Saccharomyces cerevisiae

1 Jan 2022

Abstract excerpt

Vinblastine has been used clinically as one of the most potent therapeutics for the treatment of several types of cancer. However, the traditional plant extraction method suffers from unreliable supply, low abundance, and extremely high cost. Here, we use synthetic biology approach to engineer Saccharomyces cerevisiae for de novo biosynthesis of vindoline and catharanthine, which can be coupled chemically or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37905202
DOI: 10.34133/bdr.0002

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