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Article

Production of squalene by squalene synthases and their truncated mutants in Escherichia coli.

Journal of bioscience and bioengineering - 1 Feb 2015

Katabami Akinori, Li Ling, Iwasaki Miki, Furubayashi Maiko, Saito Kyoichi, Umeno Daisuke

Abstract excerpt

Squalene is a precursor of thousands of bioactive triterpenoids and also has industrial value as a lubricant, health-promoting agent, and/or drop-in biofuel. To establish an efficient Escherichia coli-based system for squalene production, we tested two different squalene synthases and their mutants in combination with precursor pathways. By co-expressing a chimeric mevalonate pathway with human or...

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PMID: 25282635
DOI: 10.1016/j.jbiosc.2014.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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