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Article

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2012

Westfall Patrick J, Pitera Douglas J, Lenihan Jacob R, Eng Diana, Woolard Frank X, Regentin Rika, Horning Tizita, Tsuruta Hiroko, Melis David J, Owens Andrew, Fickes Scott, Diola Don, Benjamin Kirsten R, Keasling Jay D, Leavell Michael D, McPhee Derek J, Renninger Neil S, Newman Jack D, Paddon Chris J

Abstract excerpt

Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200 million new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemisinin is a sesquiterpene lactone isolated from th...

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Identifiers

PMID: 22247290
DOI: 10.1073/pnas.1110740109
PMCID: PMC3271868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22247290-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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