Article
NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches.
International journal of molecular sciences - 5 Jul 2022
Almodóvar-Payá Carmen, Guardiola-Ripoll Maria, Giralt-López Maria, Gallego Carme, Salgado-Pineda Pilar, Miret Salvador, Salvador Raymond, Muñoz María J, Lázaro Luisa, Guerrero-Pedraza Amalia, Parellada Mara, Carrión María I, Cuesta Manuel J, Maristany Teresa, Sarró Salvador, Fañanás Lourdes, Callado Luis F, Arias Bárbara, Pomarol-Clotet Edith, Fatjó-Vilas Mar
Abstract excerpt
Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of NRN1 with SZ by exploring its role on age at onset and its brain activity correlates. First, we developed two genetic...
Topics
- Adult
- GPI-Linked Proteins
- Humans
- Magnetic Resonance Imaging
- Memory, Short-Term
- Nerve Growth Factors
- Neuroimaging
- Neuropeptides
- Polymorphism, Single Nucleotide