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Article

Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype.

Neurobiology of aging - 1 Mar 2017

Janelidze Shorena, Hertze Joakim, Nägga Katarina, Nilsson Karin, Nilsson Christer, Wennström Malin, van Westen Danielle, Blennow Kaj, Zetterberg Henrik, Hansson Oskar

Abstract excerpt

Blood-brain barrier (BBB) dysfunction might be an important component of many neurodegenerative disorders. In this study, we investigated its role in dementia using large clinical cohorts. The cerebrospinal fluid (CSF)/plasma albumin ratio (Qalb), an indicator of BBB (and blood-CSF barrier) permeability, was measured in a total of 1015 individuals. The ratio was increased in patients with Alzheimer's disease,...

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Identifiers

PMID: 28061383
DOI: 10.1016/j.neurobiolaging.2016.11.017
PMCID: PMC5754327

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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