Article
Investigating the association of ApoE genotypes with blood-brain barrier dysfunction measured by cerebrospinal fluid-serum albumin ratio in a cohort of patients with different types of dementia.
PloS one - 1 Jan 2013
Karch André, Manthey Henrike, Ponto Claudia, Hermann Peter, Heinemann Uta, Schmidt Christian, Zerr Inga
Abstract excerpt
BACKGROUND: Since more than a decade ApoE is known to be a strong risk factor for Alzheimer's disease (AD); however, molecular pathways mediating this risk are still unclear. In recent years it has been hypothesized that ApoE might play a role in the disintegration of blood-brain barrier (BBB). In the present study we addressed the question if ApoE genotypes might be associated with BBB function measured by...
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