Article
The effect of somatic mutations in mitochondrial DNA on the survival of patients with primary brain tumors.
Croatian medical journal - 30 Apr 2024
Khair Siti Zulaikha Nashwa Mohd, Ab Radzak Siti Muslihah, Idris Zamzuri, Zin Anani Aila Mat, Ahmad Wan Muhamad Amir Wan, Yusoff Abdul Aziz Mohamed
Abstract excerpt
AIM: To assess the presence of mitochondrial (mt) DNA somatic mutations, determine the relationship between clinicopathological characteristics and mutations, and assess the survival outcomes in Malay patients with primary brain tumors. METHODS: The study enrolled 54 patients with primary brain tumors. DNA extracted from paired tissue and blood samples was subjected to Sanger sequencing to identify alterations in...
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