Article
Deciphering the spectrum of somatic mutations in the entire mitochondrial DNA genome.
Genetics and molecular research : GMR - 30 Apr 2015
Chen X Z, Fang Y, Shi Y H, Cui J H, Li L Y, Xu Y C, Ling B
Abstract excerpt
The mitochondrion is a crucial intracellular organelle responsible for regulating cellular energy metabolism, producing free radicals, initiating and executing the apoptotic pathways. Previous studies have shown that somatic mutations in mitochondrial DNA are associated with various tumors, which may be involved during carcinogenesis and tumor progression. To examine the mutation pattern in cancer, 625 reported...
Topics
- Base Sequence
- DNA Mutational Analysis
- DNA, Mitochondrial
- Genome, Mitochondrial
- Humans
- Mitochondria
- Mutation